Abstract: The paper focuses on the spatio-temporal analysis of the dynamics of the incidence in the population in Lviv region by the main classes of diseases for 2009-2018. Groups of factors influencing the incidence in the population and the demographic situation in general have been investigated. It was found out that each group of factors can have positive and negative effects in certain regions. The structure of the disease incidence in the population of Lviv region by classes of diseases for the period 2010-2018 has not changed. It is traditionally formed by diseases of the respiratory system, blood and blood-forming organs, circulatory system, endocrine system and neoplasms. The quantitative indicators of changes in the incidence in the population of the region until 2018 by the main classes of diseases in the context of administrative districts are calculated and analyzed. A cluster analysis was carried out to determine the spatial differentiation of the incidence in the population of Lviv region. For clustering, the main indicators were selected by classes of diseases that have the largest specific weight in the structure of morbidity. The cluster analysis made it possible to distinguish two clusters within the region, for which the characteristics in the population morbidity indicators were identified. The analysis of variance (LSD-test) showed the presence of significant differences between the incidences in the population in Lviv region on respiratory diseases. The study of the disease incidence in certain areas makes it possible to predict the state of health and to work out measures to improve the health in the population.