Abstract: Cultural routes may become interesting tourist destinations because of their thematic and traveling experience, making connections to renown places, events and personalities. The process of forming cultural routes as tourist products is considered a new principle of protection, revitalization, use and presentation of cultural heritage. Europe in particular is rich in cultural heritage originating from different historical epochs. This is why within the renown and most visited cultural routes were formed in Europe. There are 32 pan-European cultural routes, of which several routes cross Southeastern Europe. This article aims to examine the interrelation of the cultural routes within Southern Europe with those from the entire Europe. The main goal is to determine to what extent their connection to the existing routes contribute to the tourism promotion of SEE states, making them the cross-border tourist destinations.