Abstract: The territory of eastern Serbia is characterized by a variety of igneous, sedimentary and metamorphic rocks formed through different paleogeographic developments. As a result of varied natural conditions, the region is vulnerable to various geohazards, such as earthquake, landslide, excessive erosion, flood, rockfall, cave collapse and subsidence. The occurrence of any geohazard depends on the intensity of the process causing it. An assessment of each type of hazard or combination of all hazards is necessary for this region of Serbia which accommodates major power-generation, industrial and mining facilities and has rich mineral resources. Depopulation of eastern Serbia reduces the ability of local communities to invest in the hazard control works. This assessment of the geohazards begins with the reference to the available seismic maps and proceeds with the research in the landslide, potential flood and excessive erosion hazards, then rockfall and rock collapse. Research results suffice to prepare a generalized geohazard map of eastern Serbia showing areas vulnerable to particular natural hazards and to estimate a total area endangered by hazardous processes. The purpose of this work is to locate and classify areas of potential hazards on which future protective actions may be based.