Abstract: Floods are considered one of the most significant natural threats to cities and their infrastructure, especially when urban resilience is weak of floods, due to both human and natural factors. This is the case in the Algerian city of Tebessa, where urban resilience is low in the watershed of Wadi Nagues, which divides the city from north to south. Informal expansion along the riverbanks and inadequate city infrastructure increases the risk of flooding in the city. This study aims to identify the factors that increase flood hazards in Wadi Nagues and analyze maximum daily rainfall values to determine the maximum flood flow and volume during different return periods of 10, 50, 100, and 200 years, in order to map the floodplain of the river. This is accomplished using Geographic Information Systems (GIS) and HEC-RAS software for flood simulation. The results of the flood simulation in Wadi Nagues show that river waters inundate the southern areas of informal expansion, the airport, the railway, Houari Boumediene neighborhoods, and the Constantine Road – which is an economic artery for the city. The peak flow reaches 86.82 m³/h, and the volume of flow is 159.20 m³/s, in a during a 200-year return period. Field surveys also reveal several other human factors that increase the risk of flooding, such as informal expansion, lack and weakness of flood protection hydraulic structures, and poor river water cleanliness. This necessitates intervention to protect the city from flood hazard.