Abstract: Bangladesh is mainly formed by alluvial deposits, facing riverbank erosion very frequently due to unvarying alteration of river channels. This study is aimed at computing the actual bank shifting along the Manu River within Bangladesh for a period of thirteen years (1997-2010). The entire course of Manu River from upstream of India Border, Moulvibazar to the confluence with the Kushiyara River at Manumukh, Sherpur for a stretch of around 69 km has been studied using an integrated approach of Remote Sensing and Geographical Information System (GIS). The channel configuration of the Manu River has been mapped for the years 1997 and 2010 using Landsat satellite images. The analysis divulged that the Manu River is a highly meandering river with several very critical sections where the river has been suffering enormously with the erosion problem and shifting characteristics. The enumerated river shifting was found very high as the maximum left bank shifting and maximum right bank shifting had occurred at Rajnagar, Moulvibazar of 656 m and 628 m respectively, in the mentioned period. The results deliver latest and steadfast evidence on the dynamic fluvio-geomorphology of the Manu River for designing and execution of erosion control schemes.